Abstract #1454

Association of PC-MRI measured Cerebroarterial Pulsatility with Cognitive Impairment and White Matter Hyperintensity in Aged Subjects

Soroush Heidari Pahlavian^1,2, Xinhui Wang ², Samantha Ma^1,2, John Ringman², Helena Chui², Danny J.J. Wang^1,2, and Lirong Yan^1,2

¹USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, ²Department of Neurology, University of Southern California, Los Angeles, CA, United States

Elevated cerebroarterial pulsations due to arterial stiffness can impart abnormal forces to downstream capillary/tissue leading to microvascular damage, which are thought to be a contributing factor in the pathogenesis of neurodegenerative disorders such as Alzheimer’s disease and small vessel disease. In this study, we assessed the utility of two-dimensional (2D) phase-contrast MRI (PC-MRI) in quantifying cerebroarterial pulsations and evaluated the associations of pulsatile and non-pulsatile hemodynamic measures with cognitive performance and white matter hyperintensity (WMH). Our results indicated significant associations of PC-MRI derived pulsatility metrics with cognitive performance and WMH.

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