Abstract #1441

Uncharted Waters: Insights From A 100-Subject Myelin Water Imaging Atlas

Taylor Swift-LaPointe¹, Irene M. Vavasour^2,3, Lisa Eunyoung Lee⁴, Shawna Abel⁴, Bretta Russell-Schulz², Carina Graf^1,3, Anika Wurl¹, Hanwen Liu^1,3, Cornelia Laule^1,2,3,5, David K.B. Li^2,4, Anthony Traboulsee⁴, Roger Tam^2,6, Lara A. Boyd⁷, Alex L. MacKay^1,2, Shannon H. Kolind^1,2,3,4, and Adam V. Dvorak^1,3

¹Physics and Astronomy, University of British Columbia, Vancouver, BC, Canada, ²Radiology, University of British Columbia, Vancouver, BC, Canada, ³International Collaboration on Repair Discoveries (ICORD), Vancouver, BC, Canada, ⁴Medicine (Neurology), University of British Columbia, Vancouver, BC, Canada, ⁵Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada, ⁶Biomedical Engineering, University of British Columbia, Vancouver, BC, Canada, ⁷Department of Physical Therapy, University of British Columbia, Vancouver, BC, Canada

Data from 100 healthy volunteers (58F/42M, mean age 41 years, range 20-78 years) scanned at 3.0T were used to create a structural template. Voxel-wise mean myelin water fraction (MWF) and intra/extracellular T₂ (IET2) atlases were created, and 19 regions of interest were obtained using the joint label fusion framework. Pearson correlations with both age and sex were calculated for MWF and IET2. Mean MWF and IET2 demonstrated clear ranking between brain structures for different age groups, indicating that relative metric values are generally consistent between ROIs. There were no significant correlations between MWF or IET2 and sex.

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