Abstract #1435

Myelin water imaging of Amyoplasia: Comparison to a control atlas

Bretta Russell-Schulz¹, Irene M Vavasour^1,2,3, Hanwen Liu^2,4, Cornelia Laule^2,3,4,5, Erin L MacMillan^1,6,7, Alex L MacKay^1,3,4, Carolyn Sparrey^2,8, and Bonita Sawatzky^2,9

¹UBC MRI Research Centre, University of British Columbia, Vancouver, BC, Canada, ²International Collaboration on Repair and Discoveries (ICORD), University of British Columbia, Vancouver, BC, Canada, ³Radiology, University of British Columbia, Vancouver, BC, Canada, ⁴Physics & Astronomy, University of British Columbia, Vancouver, BC, Canada, ⁵Pathology & Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada, ⁶SFU ImageTech Lab, Simon Fraser University, Surrey, BC, Canada, ⁷Philips Canada, Marham, ON, Canada, ⁸School of Mechatronic Systems Engineering, Simon Fraser University, Surrey, BC, Canada, ⁹Orthopaedics, University of British Columbia, Vancouver, BC, Canada

Adults living with Amyoplasia report lower physical activity but no educational or cognitive impairment. Myelin water fraction (MWF) is a quantitative MRI metric useful for examining white matter myelin content. We expect brain MWF to be similar or higher between Amyoplasia and controls in most of the brain but lower in areas associated with physical ability. In 3 adults with Amyoplasia MWF maps were created using a 32-echo T2 GRASE compared to an open-source healthy control atlas. Small reductions in corticospinal tract myelin were observed, while the remainder of the brain examined was similar to the control atlas.

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