Emerging evidence indicates
that myelination and axonal abnormalities could lead to alterations of brain
connectivity, contributing to a myriad of neurological disorders. Measurement of myelin to axonal volume, as
defined by the g-ratio, has been shown to represent a sensitive and specific
metric of neurodevelopment and neurodegeneration. However, only a single study to
date has sought to evaluate age-related differences in g-ratio in the adult
human brain. Here, we introduce and compare two novel approaches to g-ratio
mapping. Both methods revealed a quadratic relationship between g-ratio and age
in a large cohort of cognitively unimpaired participants.
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