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Abstract #1408

Microstructure changes in secondary progressive multiple sclerosis measured using advanced quantitative MRI of the brain and spine

Marco Battiston1, Carmen Tur1,2, Marios C. Yiannakas1, Francesco Grussu1,3, Torben Schneider4, Daniele Martinelli5, Baris Kanber6, Ferran Prados1,6,7, Patrizia Pajak1, Olga Ciccarelli1, Rebecca S. Samson1, and Claudia A.M. Gandini Wheeler-Kingshott1,8,9
1NMR Research Unit, UCL Queen Square MS Centre, Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, London, United Kingdom, 2Neurology Department, , Luton and Dunstable University Hospital, Luton, United Kingdom, 3Centre for Medical Image Computing, Department of Computer Science, University College London, London, United Kingdom, 4Philips Healthcare, Guilford, United Kingdom, 5IRCCS Mondino Foundation, Pavia, Italy, 6Centre for Medical Image Computing, Medical Physics and Biomedical Engineering, University College London, London, United Kingdom, 7Universitat Oberta de Catalunya, Barcelona, Spain, 8Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy, 9Brain MRI 3T Center, IRCCS Mondino Foundation, Pavia, Italy

Multiple Sclerosis (MS) is a complex disease whose mechanisms of progression still remain unclear. The use of quantitative MRI techniques in a multi-modal fashion, i.e. acquisition of more than one contrast type, can help to non-invasively measure changes in the tissue at a microstructural level during the disease course. Moreover, evidence of spinal cord involvement and its role in the diagnosis and prognosis is mounting. Here, we aim to address both needs by developing a multi-modal qMRI protocol for joint investigation of brain and spinal cord microstructure, and we report findings from a small cohort of people with MS.

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