Evidence from histopathological studies has demonstrated the involvement of the peripheral nervous system in multiple sclerosis (MS), specifically alteration in myelin content and, to a lesser extent, axonal degeneration. However, evidence from objective investigations in vivo is lacking. In this pilot study, the lumbar plexus and the sciatic nerve are investigated in people with MS using a previously optimised magnetisation transfer ratio (MTR) protocol developed in healthy controls. Results demonstrate reduced MTR values in both anatomical regions studied, consistent with histopathological data, and as such highlighting a need for further investigations in a larger sample population.
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