Abstract #1385

Trajectories of magnetic susceptibility in the pulvinar provide further evidence for accelerated decline of thalamic iron in multiple sclerosis

Fahad Salman¹, Robert Zivadinov^1,2, Niels Bergsland³, Michael G. Dwyer¹, Bianca Weinstock Guttman⁴, and Ferdinand Schweser^1,5

¹Neuroimaging, Buffalo Neuroimaging Analysis Center, Buffalo, NY, United States, ²MRI Clinical and Translational Research Center, Buffalo, NY, United States, ³Neurology, Buffalo Neuroimaging Analysis Center, Buffalo, NY, United States, ⁴Neurology, Jacobs Comprehensive MS Center for Treatment & Research, Buffalo, NY, United States, ⁵Neurology, MRI Clinical and Translational Research Center, Buffalo, NY, United States

Several recent cross-sectional studies have observed decreasedmagnetic susceptibility in the thalamus of patients with multiple sclerosis (MS) using Quantitative Susceptibility Mapping (QSM).However, the concavity of the iron concentration trajectory in normal aging renders the interpretation of findings of the previous studies difficult. In the present work, we applied QSM longitudinally in conjunction with a dedicated analysis procedure to obtain optimal longitudinal measurement accuracy. Our longitudinal results confirm previous cross-sectional findings and suggest that thalamic QSM may serve as an imaging marker for disease progression in MS.

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