In this study, we used dynamic functional connectivity (dFC) to characterize time-varying connectivity abnormalities in patients with multiple sclerosis (MS) with the main disease phenotypes. Compared to controls, MS patients presented overall dFC reduction in all networks, along with increased dFC in sensorimotor, default-mode and frontal/attention networks. While progressive MS showed additional dFC decrease vs relapsing-remitting (RR) MS, in benign MS the overall reduction of dFC was accompanied by significantly increased dFC in the sensorimotor, default-mode and frontal/attention networks. Reduced dFC correlated with more severe clinical disability and worse cognitive performance.
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