Abstract #1376

Declining frontoparietal connectivity is linked to decreased episodic memory performance in multiple sclerosis

Katherine A Koenig¹, Jian Lin¹, Daniel Ontaneda², Kedar Mahajan², Jenny Feng², Stephen M. Rao³, Sanghoon Kim¹, Stephen J Jones¹, and Mark J Lowe¹

¹Imaging Sciences, The Cleveland Clinic, Cleveland, OH, United States, ²Neurological Institute, The Cleveland Clinic, Cleveland, OH, United States, ³Schey Center for Cognitive Neuroimaging, The Cleveland Clinic, Cleveland, OH, United States

Cognitive dysfunction, often including memory loss, impacts about half of those with Multiple Sclerosis (MS). Our work aims to develop a predictor of future memory decline in MS. Using high resolution MRI, we measured resting state functional connectivity of the frontoparietal network in 77 participants with MS. We found that connectivity was related to episodic memory at baseline, and that the one-year change in connectivity was related to the change in memory performance. This finding suggests that functional connectivity can be developed as a predictor of memory decline in MS.

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