Cross-cortical interactions in the human brain remain poorly understood and are often over-simplified as a 2-dimensional cortical model in fMRI studies. To date, high-resolution fMRI has been limited to relatively small brain slabs that cover particular areas of interest, providing fine mapping of local circuits but precluding macroscale analysis. Here, an EPIK sequence was used to measure the GE-BOLD signal from individual cortical layers through most of the brain. The combination of high resolution (0.63 mm isotropic) and large coverage fMRI enabled identification of long-distance neuronal interactions that take place between particular cortical depths during resting-state.
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