Spindle is one of the most critical brain oscillatory activities that has been shown to mediate sensory transmission and memory consolidation. However, where and how spindle-related activities are distributed at the systems level and their brain-wide propagation targets remain elusive. In this study, we demonstrate the first integrative view of the causal recruitment of brain-wide networks by thalamo-cortically initiated spindle-related activities in a temporal-frequency specific manner and verified its role in facilitating memory consolidation.
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