Enhanced endothelial permeability is an important hallmark of atherosclerotic plaques at high-risk for causing severe cardiovascular events. Here we present a the application of a novel, self-gated DCE-MRI acquisition combined with compressed sensing reconstruction to quantify endothelial permeability in the mouse aortic root. In a longitudinal natural disease progression study in ApoE-/- mice, we find that plaque contrast agent washout computed from this acquisition changes significantly over time, with washout being slower in older mice.
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