Static FC changes in neurodegeneration can indicate underlining neural mechanism pathology present in pre-manifest disease stage. In addition to the spatial FC component, quasi-periodic patterns (QPPs) implement spatiotemporal information of neural activity, allowing integrated assessment of possible initial changes in large-scale brain dynamics. We measured Low Frequency (LF) BOLD changes using rsfMRI in Q175 HD mouse model at 3 and 12 months of age. Results indicate decreased FC between specific regions in heterozygous compared to wild-type mice at 12 months. Both at 3 and 12 months, additional QPPs are present in the heterozygous group, deviating from the wild type group.
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