Abstract #1240

Diminished default mode network connectivity in older individuals is associated with aberrant brain metabolism

Xirui Hou¹, Zixuan Lin¹, Peiying Liu¹, Corinne Pettigrew², Anja Soldan², Marilyn Albert², and Hanzhang Lu¹

¹The Russell H. Morgan Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, United States

Cerebral metabolic rate of oxygen (CMRO₂), the rate at which O₂ is consumed in the brain, is thought to be a direct index of energy hemostasis and brain health. Recent studies have suggested that CMRO₂ is elevated but functional connectivity is declined with age. In this work, we demonstrated the diminished default network was associated with aberrant CMRO₂ in older healthy subjects. Network analysis indicated that the increasing amount of CMRO₂ was used to compensate for the inefficiency of degraded networks.

This abstract and the presentation materials are available to members only; a login is required.

Join Here