Abstract #1237

Disrupted Small-World Networks and Differences in Metabolite Concentration in Healthy Adults with Low and High Genetic Risk

Hui Zhang^1,2, Pui Wai Chiu^1,3, Isaac Ip⁴, Tianyin Liu⁵, Gloria Hoi Yan Wong⁵, You-Qiang Song⁶, Savio Wai Ho Wong⁴, Queenie Chan⁷, Karl Herrup⁸, and Henry Ka Fung Mak^1,2,3

¹Department of Diagnostic Radiology, The University of Hong Kong, Hong Kong, Hong Kong, ²Alzheimer's Disease Research Network, Hong Kong, Hong Kong, ³State Key Laboratory of Brain and Cognitive Sciences, Hong Kong, Hong Kong, ⁴Department of Educational Psychology, the Chinese University of Hong Kong, Hong Kong, Hong Kong, ⁵Department of Social Work and Administration, The University of Hong Kong, Hong Kong, Hong Kong, ⁶Department of Biochemistry, The University of Hong Kong, Hong Kong, Hong Kong, ⁷Philips Healthcare, Hong Kong, Hong Kong, ⁸Alzheimer Disease Research Centre, University of Pittsburgh, Pittsburgh, PA, United States

To identify the relationship between the topological properties and glutamate in genetic-related subgroups (ApoE4 carriers and non-ApoE4 carriers), combined resting state fMRI (rs-fMRI) and MRS were applied in this study. Graph theory metrics of subgroups were calculated and compared. In the results, ApoE4 carriers had worse network segregation and integration. However, there was significant correlation between [Glx]_abs in left hippocampus and topological metrics in high-risk group. We postulated that glutamatergic synaptic transmission modulates rs-fMRI activities in ApoE4 carriers.

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