Abstract #1232

In-vivo laminar CBF fMRI using high-resolution pseudo-continuous arterial spin labeling at 7T

Xingfeng Shao¹, Kay Jann^1,2, Kai Wang¹, Fanhua Guo³, Peng Zhang³, and Danny JJ Wang^1,2

¹Mark & Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, ²Department of Neurology, University of Southern California, Los Angeles, CA, United States, ³State Key Laboratory of Brain and Cognitive Science, Beijing MRI Center for Brain Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China

In-vivo laminar CBF fMRI was performed by high resolution (0.5×0.5×1.5 mm³) inner-volume GRASE with optimized pCASL labeling at 7T. Activation of finger-tapping task (5 blocks, TA=10 min) was reliably detected in all 4 subjects. Both rest/FT CBF peaks in the middle layers, which corresponds to highest capillary density in cortex layer IV. FT evoked CBF increase shows one peak in middle layer, and a second shoulder in deep layer. The capability to provide quantitative CBF measurements at both baseline and task activation with high specificity to neuronal activities is a unique strength of ASL fMRI compared to other fMRI techniques.

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