In the past decade, passband bSSFP has emerged as an alternative method to the widely-used GE-EPI in fMRI studies at high-fields. Multiline bSSFP with an interleaved phase-encoding order was further proposed to accelerate bSSFP fMRI. However, it intrinsically suffers from high spatial frequency ghosts which blur the image. In this study, we developed a multi-echo bSSFP sequence using a sequential phase-encoding order, combined with the GRAPPA technique for ghost elimination. In vivo experiments demonstrated that this sequence could shorten the imaging time and provide high-quality structural and functional MR images of the human brain at 7T with sub-millimeter resolution.
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