Abstract #1109

Voxel-wise CMRO2 mapping reveals focally-reduced task-related oxygen consumption in multiple sclerosis

Eleonora Patitucci¹, Rachael C Stickland ², Hannah L Chandler¹, Michael Germuska¹, Catherine Foster¹, Sharmila Khot¹, Neeraj Saxena¹, Valentina Tomassini^1,3, and Richard G Wise^1,3

¹CUBRIC - Cardiff University Brain Research Imaging Centre -Psychology, Cardiff University, Cardiff, United Kingdom, ²Department of Physical Therapy and Human Movement Sciences, Northwestern University, Chicago, IL, United States, ³Institute for Advanced Biomedical Technologies (ITAB), Department of Neurosciences, Imaging and Clinical Sciences, University of Chieti-Pescara “G. d’Annunzio”, Chieti, Italy

Calibrated fMRI can map the rate of cerebral oxygen consumption of the human brain, offering an important indicator of energy dysfunction in neurodegenerative and neuroinflammatory diseases. Previous studies investigated oxygen metabolism at rest or in response to tasks within BOLD signal defined region of interests (ROIs). Here, we investigate on a voxel-by-voxel basis the oxygen metabolic activity in patients with multiple sclerosis during the execution of a task. We show the feasibility of mapping task-induced CMRO₂ changes, demonstrating reduced oxygen consumption in the basal ganglia in MS patients that was not otherwise evident from BOLD or CBF signals.

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