Abstract #1092

Cardiac Diffusion Tensor MRI Using M2-gSlider with a Real-Time Slice Tracking Respiratory Navigator

Christopher Nguyen^1,2,3, Timothy G Reese^3,4, Congyu Liao^3,4, William J Kostis⁵, Marcel P Jackowski⁶, Kawin Setsompop^3,4, and Choukri Mekkaoui^3,4

¹Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, MA, United States, ²Department of Medicine, Harvard Medical School, Boston, MA, United States, ³Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, ⁴Department of Radiology, Harvard Medical School, Boston, MA, United States, ⁵Cardiovascular Institute, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, United States, ⁶Department of Computer Science, University of São Paulo, São Paulo, Brazil

Free-breathing isotropic cardiac diffusion tensor MRI (DT-MRI) of the left ventricle can be performed using second moment (M2) motion compensated spin echo encoding and generalized slice dithered enhanced resolution (gSlider). This technique provides substantial improvements in spatial resolution and consequently in the accuracy of diffusion-based indices. However, M2-gSlider’s RF slice encoding is susceptible to through-slice motion, limiting the maximal improvement in slice resolution. Here, we evaluate the addition of a slice tracking respiratory navigator (NAV) to prospectively adjust slice position in real-time. M2-gSlider-NAV was validated in healthy volunteers and tested in a patient with a history of myocardial infarction.

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