This study proposed a new method that can directly visualize and assess the collateral status by post-processing multiphase perfusion-weighted images (PWI) generated by multi-inversion time arterial spin labeling (mTI-ASL), and evaluate its performance by comparison with digital subtraction angiography (DSA) in patients with ischemic stroke. Comparison of the results of 28 patients showed that the collateral status assessed by the 3D mTI-ASL grading system was greatly consistent (kappa coefficient k = 0.854) with DSA. This technique is promising for the noninvasive assessment of the collateral status in stroke patients.
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