Quantitative T1ρ imaging has been studied for evaluating changes in tissue composition, in particular for detecting early cartilage degeneration in osteoarthritis. Magnetic resonance fingerprinting (MRF) provides a framework for rapid, robust acquisition of quantitative tissue property maps. Simulation experiments using spin-lock prepared MRF with different pulse schedules were conducted to demonstrate the feasibility of quantification of T1ρ in addition to T1 and T2. All tested sequences were sensitive to T1ρ and produced tissue property maps with major structures of interest. Differing accuracy and precision between sequences suggests opportunities for optimizing MRF for simultaneous T1, T2, and T1ρ quantification.
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