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Abstract #1011

Large-scale quantitative atlases over the whole adult age range

Gian Franco Piredda1,2,3, Peipeng Liang4, Tom Hilbert1,2,3, Hongjian He5, Jean-Philippe Thiran2,3, Yi Sun6, Jianhui Zhong5,7, Kuncheng Li8,9, and Tobias Kober1,2,3
1Advanced Clinical Imaging Technology, Siemens Healthcare AG, Lausanne, Switzerland, 2Department of Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland, 3LTS5, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, 4School of Psychology, Capital Normal University, Beijing Key Laboratory of Learning and Cognition, Beijing, China, 5Center for Brain Imaging Science and Technology, Key Laboratory for Biomedical Engineering of Ministry of Education, College of Biomedical Engineering and Instrumental Science, Zhejiang University, Hangzhou, Zhejiang, China, 6MR Collaboration, Siemens Healthcare Ltd., Shanghai, China, 7Department of Imaging Sciences, University of Rochester, Rochester, NY, United States, 8Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, China, 9Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing, China

It was recently shown that brain atlases of normative relaxation times enable automated detection of tissue alterations on a single-subject basis. In this work, normative quantitative T1 and T2 atlases were obtained from a large-scale adult cohort of healthy volunteers (#997) covering a comprehensive age range (19-72y) in a multi-centric study including eleven sites. Atlases were derived by linearly modelling the inter-subject variability of T1/T2 while accounting for effects such as gender and age differences. Travelling subjects were scanned in nine centers with the same protocol, the comparison of the acquired maps showed good reproducibility of the employed relaxometry sequences.

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