Abstract #0978

Distortion-free, submillimeter-isotropic-resolution diffusion MRI with gSlider BUDA-EPI and multi-coil dynamic B0 shimming

Congyu Liao¹, Berkin Bilgic¹, Qiyuan Tian¹, Jason Stockmann¹, Qiuyun Fan¹, Siddharth Srinivasan Iyer^1,2, Fuyixue Wang^1,3, Chanon Ngamsombat^1,4, Xiaozhi Cao¹, Mary Kate Manhard¹, Susie Y. Huang¹, Lawrence L. Wald¹, and Kawin Setsompop¹

¹Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States, ²Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, United States, ³Harvard-MIT Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, United States, ⁴Department of Radiology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Thailand

Diffusion magnetic resonance imaging (dMRI) is a highly sensitive imaging modality, but is limited in spatial resolution and signal-to-noise ratio (SNR). In this work, we combine an SNR-efficient acquisition and model-based reconstruction strategies with newly-available hardware instrumentation to achieve distortion-free in-vivo dMRI at 600-860 µm isotropic voxel size with high fidelity and sensitivity on a clinical 3T scanner. At this resolution, it is possible to accurately probe the microstructure of different cortical layers in the human brain.

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