Urinary tract obstructions (UTOs) are impairments in urine flow which can lead to pain, infection and irreversible kidney damage if left undiagnosed or untreated. Chemical exchange saturation transfer (CEST) is a novel MRI contrast mechanism that is particularly sensitive to environmental changes including changes in pH values. In this study we developed a protocol by administering the FDA approved iopamidol to obtain dynamic pH and perfusion MRI contrast maps of the kidneys and compared these with iopamidol administered multi-phase CT in a unilateral urinary obstruction mouse model.
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