Abstract #0945

Travelling kidneys: Multicentre multivendor variability of renal diffusion-weighted imaging – preliminary results

Fabio Nery¹, Charlotte Buchanan², Andrew Priest³, João Sousa⁴, Michael Nation⁵, Iosif Mendichovszky³, Steven Sourbron⁶, Susan Francis², and David Thomas^7,8,9

¹UCL Great Ormond Street Institute of Child Health, London, United Kingdom, ²Sir Peter Mansfield Imaging Centre, University of Nottingham, University Park, Nottingham, United Kingdom, ³Department of Radiology, Addenbrooke’s Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom, ⁴Imaging Biomarkers Group, Department of Biomedical Imaging Sciences, University of Leeds, Leeds, United Kingdom, ⁵Kidney Research UK, Peterborough, United Kingdom, ⁶Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, United Kingdom, ⁷Neuroradiological Academic Unit, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom, ⁸Dementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom, ⁹Wellcome Centre for Human Neuroimaging, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom

Multicentre validation studies are required to enable clinical translation of renal MRI biomarkers. Here, we report on the feasibility of standardising renal diffusion weighting imaging protocols and on the variability of renal apparent diffusion coefficient across a range of vendors. Results suggest feasibility of implementing near-identical renal diffusion weighted imaging acquisition protocols with product sequences and the potential of the apparent diffusion coefficient as a robust metric to characterise renal microstructure in multi-centre studies.

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