The measurement of tubular volume fraction changes in the kidney may be valuable as a confounder of T2*-derived tissue oxygenation and as a potential biomarker. Diffusion weighted imaging provides information about in-vivo water mobility which can be linked to three sources: tissue water diffusion, blood perfusion within intrarenal microvasculature, and tubular fluid. In this work we explore the feasibility of assessing tubular volume fraction changes using the non-negative least squares (NNLS) approach under different physiological conditions.
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