Tract-based spatial statistics investigations of temporal lobe epilepsy (TLE) have been using standard diffusion metrics, without distinguishing patients according to the lateralization of their epileptogenic zone. The aim of this study is to further our knowledge by identifying specific patterns of alteration in left and right TLE patients using diffusion kurtosis imaging and NODDI parameter maps. Our findings demonstrate the presence of specific patterns of white matter alterations, with the left TLE more widely affecting both cerebral and cerebellar regions. These results support the need to consider patients separately, according to the side of their pathology.
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