Abstract #0929

Simultaneous 18F-FDG-PET and 1H-MRSI Metabolic Imaging in Epilepsy Patients: A Feasibility Study

Hui Huang¹, Miao Zhang², Rong Guo^3,4, Yudu Li^3,4, Yibo Zhao^3,4, Jialin Hu¹, Hongping Meng², Xinyun Huang², Xiaozhu Lin², Wei Liu⁵, Biao Li², Bomin Sun⁵, Yao Li¹, Zhi-Pei Liang^3,4, and Jie Luo¹

¹Institute of Medical Imaging Technology, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China, ²Department of Nuclear Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, ³Department of Electrical and Computer Engineering, University of Illinois at Urbana Champaign, Urbana, IL, United States, ⁴Beckman Institute for Advanced Sciences and Technology, University of Illinois at Urbana Champaign, Urbana, IL, United States, ⁵Department of Functional Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

PET and MRSI could provide metabolic information of the epileptogenic zone, which could add value to presurgical planning of epilepsy patients. This study investigated the feasibility of simultaneous high-resolution MRSI and ¹⁸F-FDG-PET for whole brain imaging in epilepsy patients, and studied the correlation between metabolic changes found in MRSI and hypometabolism found in FDG-PET. Our experimental results showed a decrease in NAA and an increase in Cho, concomitant with low FDG uptake.

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