Abstract #0919

Altered neurometabolic changes in acute mild traumatic brain injury patients: a SPICE study

Tianyao Wang¹, Jialin Hu², Danni Wang², Yujie Hu², Jiahua Sun³, Jun Liu¹, Yudu Li^4,5, Rong Guo^4,5, Yibo Zhao^4,5, Ziyu Meng^2,4, Zhipei Liang^4,5, and Yao li^2,6

¹Radiology department, The Fifth People's Hospital of Shanghai, Shanghai, China, ²Institute for Medical Imaging Technology, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China, ³Neurosurgery department, The Fifth People's Hospital of Shanghai, Shanghai, China, ⁴Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ⁵Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ⁶Med-X Research Institute, Shanghai Jiao Tong University, Shanghai, China

Mild traumatic brain injury (mTBI) is the most prevalent form of brain injury but the underlying physiological mechanisms are still not fully understood. MRSI has long been recognized as a potentially powerful tool for detection of neurometabolic alterations induced by TBI but most existing studies are limited by low resolution. In this study, we used a 3D high-resolution MRSI technique, known as SPICE, to study neurometabolic alterations in acute mTBI patients. Our experimental results showed various metabolic changes in different areas of patients, which lay a foundation for further investigation to gain new insights into the pathophysiology underlying acute mTBI.

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