Multi-parametric MRI was correlated with in vivo Fibred Confocal Fluorescence Microscopy and histology in two preclinical models of cryptococcosis. Increased ADCs and T2 relaxation times were linked to differences in capsule size and associated fungal density in brain lesions caused by the two pathogenic fungi Cryptococcus neoformans and C. gattii. This provides not only a non-invasive means to assess one of the most important virulence factors of Cryptococci in preclinical research but may also affect patient management by providing a method for differential diagnosis.
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