Abstract #0861

Multidimensional Diffusion MRI Assists Myelin-sensitive Bound Pool Fraction in Differentiating Microstructural Maturity of Primate Brains

Yi He¹, Henrik Lundell¹, Ines Mexia Rodrigues¹, Matthew D. Budde², Mark D. Does³, Maurice Ptito^4,5, and Tim Bjørn Dyrby¹

¹Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark, ²Neurosurgery, Medical College of Wisconsin, Milwaukee, WI, United States, ³Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, United States, ⁴School of Optometry, Université de Montréal, Montreal, QC, Canada, ⁵Department of Nuclear Medicine, University of Southern Denmark, Odense, Denmark

Myelin-sensitive bound pool fraction (BPF) enables the tracking process of myelination in primate brains. The 3D BPF maps demonstrated rapid development of myelination from a 2-day-old brain to a 12-month-old brain and a slower increase from 12 months to 30 months. Even though the process of myelination is slow, multidimensional diffusion MRI indices are indeed helpful in significantly differentiating the microstructural maturity of primate brains. Our findings suggest that both indices, isotropic kurtosis (MK_I, associated with cell density variance) and microscopic anisotropy (MK_A, correlated with cell eccentricity) are significant imaging markers for microstructural differentiation in the development of primate brains.

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