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Abstract #0829

Early Prediction of Treatment Response and Mortality in Advanced Cervical Cancer: Temporal Changes of Functional MRI and 18FDG PET/CT Radiomics

Murat Alp Oztek1,2, Stephen R Bowen2, Savannah C Partridge1, Daniel S Hippe1, William T. Yuh1, Aaron S Nelson3, Simon S Lo2, Elaine Y Lee4, Eric Leung5, John C Grecula6, Matthew Harkenrider7, Michael V Knopp6, Wei Wu1, and Nina A Mayr2
1Radiology, University of Washington, Seattle, WA, United States, 2Radiation Oncology, University of Washington, Seattle, WA, United States, 3MIM Software, Beachwood, OH, United States, 4Radiology, The University of Hong Kong, Hong Kong, Hong Kong, 5Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada, 6Ohio State University, Columbus, OH, United States, 7Loyola University, Chicago, IL, United States

DCE, ADC and 18FDG PET/CT radiomics parameters, obtained simultaneously before, early during and midway during ongoing radiation/chemotherapy correlate with tumor response and particularly mortality, and can serve as early predictors of treatment outcome in advanced cervical cancer. Longitudinal development of functional heterogeneity may be a sensitive measure reflecting responsiveness of individual tumors to a specific cytotoxic treatment regimen. Particularly the persistence of skewness of the dynamic contrast enhancement within the tumor volume predicted cancer mortality. Functional radiomics assessment may help address the unmet need for a patient- and treatment-specific early indicator of tumor responsiveness and survival.

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Abstract