Triple Network Hypothesis-related disrupted connections are associated with positive and negative symptoms in first-episode schizophrenia

Schizophrenia is one complex mental disorder. However the dysregulated cross-network interactions among the SN, CEN and DMN and how they contributed to different symptoms is still not clear. By analyzing network interactions among the SN, CEN and DMN in patients and controls using DCM,as well as the relationship between network dynamics and clinical symptoms, our study provides strong evidence for the dysregulation among SN, CEN and DMN in a triple-network perspective in first-episode schizophrenia. We further proved that the connection between DMN and CEN could be clinically-relevant neurobiological signature of schizophrenia symptoms.