Abstract #0737

Diffusion ground truth quantification of axon scale phantom: Limits of diffusion MRI on 7T, 3T and Connectome 1.0

Sudhir Pathak¹, Walter Schneider¹, Anthony Zuccolotto², Susie Huang³, Qiuyun Fan⁴, Thomas Witzel⁵, Lawrence Wald⁴, Els Fieremans⁶, Michal E. Komlosh⁷, Dan Benjamini⁷, Alexandru V Avram⁷, and Peter J. Basser⁷

¹University of Pittsburgh, Pittsburgh, PA, United States, ²Psychology Software Tools, Inc, Pittsburgh, PA, United States, ³Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, United States, ⁴Department of Radiology, Massachusetts General Hospital, Boston, MA, United States, ⁵Massachusetts General Hospital, Boston, MA, United States, ⁶Department of Radiology, New York University, New York City, NY, United States, ⁷National Institutes of Health, Bethesda, DC, United States

We have constructed a novel Taxon (textile water filled tubes) anisotropic diffusion phantom to provide “ground truth” verification of the current limits of diffusion imaging.This phantom is designed to contain 0.8 micron ID tubes with, a packing density of 10⁶ per mm² , matched to human axon histology, and allows parametric control of diameters, density, and angle dispersion. On a 7T small-bore scanner, we report the ability to distinguish fine Taxon diameter changes between 2-5 micron diameters and approximate 5 micron ID tubes on the 3T Connectome. This is approaching the anatomical scale of axons found in human brain.

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