High gradient amplitude, high gradient slew rate, and high peripheral nerve stimulation thresholds are required for oscillating gradient spin-echo (OGSE) diffusion imaging on human MRI systems. With 200 mT/m amplitude and 500 T/m/s slew rate, the MAGNUS head gradient coil was used to evaluate OGSE imaging in six healthy subjects at frequencies up to 100 Hz and b=450 s/mm2. Comparisons were made against standard pulsed gradient spin-echo (PGSE) diffusion in-vivo, which show up to 27% increased OGSE diffusivity, excellent linear correlation with frequency, and correlation length scales of 0.8µm in white matter. Diffusivity changes were negligible in an isotropic phantom.
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