Abstract #0571

Quantitative Evaluation of Tumor-related Vessels on Ultrafast Dynamic Contrast-enhanced MRI: Image Biomarker of Breast Cancer Proliferation

Kango Kawase¹, Masako Y Kataoka², Tomohiro Takemura¹, Takuto Fukutome¹, Kojiro Yano³, Maya Honda², Mami Iima², Dominik Marcel Nickel⁴, Tatsuki Kataoka⁵, Masakazu Toi⁶, and Kaori Togashi²

¹Faculty of Medicine, Kyoto University, Kyoto, Japan, ²Department of Diagnostic Imaging and Nuclear Medicine,, Kyoto University Graduate School of Medicine, Kyoto, Japan, ³Osaka Institute of Technology, Osaka, Japan, ⁴Siemens Healthcare GmbH, Erlangen, Germany, ⁵Department of Diagnostic Pathology, Kyoto University Graduate School of Medicine, Kyoto, Japan, ⁶Department of Breast Surgery, Kyoto University, Kyoto, Japan

For quantitative evaluation of tumor-related vessels, convolution filter processing was applied to ultrafast dynamic contrast-enhanced (UF-DCE) MRI of 51 lesions to obtain vessel length and crossing count as quantitative markers. The current analysis showed that these imaging markers were associated with a subtype of invasive breast cancer, the Ki-67 index, among invasive breast cancers. This opens a new approach to the evaluation of tumor-related vessels and tumor microenvironment.

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