Abstract #0556

Hyperpolarized 129Xe functional brain mapping

Yurii Shepelytskyi^1,2, Francis T Hane^2,3, Vira Grynko^1,2, Tao Li³, Ayman Hassan⁴, and Mitchell S Albert^2,3,5

¹Chemistry and Materials Science Program, Lakehead University, Thunder Bay, ON, Canada, ²Thunder Bay Regional Health Research Institute, Thunder Bay, ON, Canada, ³Chemistry, Lakehead University, Thunder Bay, ON, Canada, ⁴Thunder Bay Regional Health Science Centre, Thunder Bay, ON, Canada, ⁵Northern Ontario School of Medicine, Thunder Bay, ON, Canada

Functional magnetic resonance imaging (fMRI) localizes active regions of the brain during brain stimuli. In this work, we demonstrate hyperpolarized (HP) ¹²⁹Xe fMRI in two classical fMRI experiments: a flashing visual stimulus and a fist-clenching motor stimulus. Using a chemical shift saturation recovery (CSSR) pulse sequence, our processed images localize brain activity to regions of the brain correlated to those identified using conventional Blood Oxygenation Level Dependent fMRI. The sensitivity of Xe fMRI was nearly two orders of magnitude greater than that of BOLD fMRI. In addition, ¹²⁹Xe fMRI allows presenting stimuli with significantly smaller repetition frequencies.

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