Abstract #0550

A real-time quantitative method of Gd-DTPA concentration in neuroimaging using T1 3D MP-RAGE sequence at 3.0T

Yumeng Cheng^1,2,3, Hongbin Han^1,2,3, Yajuan Gao^2,3, Rui Wang^2,3, Yu Song³, Xianjie Cai^1,2,3, and Zeqing Tang^1,2,3

¹Institute of Medical Technology(IMT), Peking University Health Science Center(PKUHSC), Beijing, China, ²Department of Radiology, Peking University Third Hospital, Beijing, China, ³Key Laboratory of Magnetic Resonance Imaging Equipment and Technique, Beijing, China

We proposed a simple quantitative method based on the linear relationship between MR signal enhancement and Gd-DTPA concentration (C) by using T1 3D MP-RAGE for the real-time in vivo measurement of Gd-DTPA concentration in neuroimaging at 3.0 T. A good linear relationship between ΔSI and Gd-DTPA concentration existed over the concentration range of 0–1 mM (R2=0.985). Further, six human subjects with different brain tumors were enrolled for in vivo application of the novel method. All the results revealed that the quantitative method presented by our study is accurate, real-time and applicable.

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