Blood-brain barrier (BBB) plays a very important role in regulating water and nutrients delivery between vascular circulation and central nervous system (CNS). Any disruption in the blood brain barrier may cause the alteration of normal functional activity of the nervous system. The techniques currently available to measure BBB permeability are prone to certain limitations and potential side effects. In this study we demonstrated a non-invasive technique of evaluating BBB permeability using the magnetization transfer (MT) effect on endogenous water labeled by arterial spin labeling (ASL) technique as a perfusion tracer.
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