Perfusion quantification is important for the diagnosis of many diseases. Validation of perfusion quantification methods remains challenging due to the various assumptions and lack of the ground truth. We built a numerical phantom of microvascular network in the kidney. In the phantom, the ground truth blood velocity and flow were computed from Navier-Stokes equation. Tracer concentration was simulated based on the mass transport equation. Comparison between Kety's method and our recently proposed AIF-free QTM method was performed using the numerical phantom. It turns out that QTM method reduces the flow error by more than 3 folds compare with Kety's method.
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