Abstract #0503

CEST and qMT Properties of Brain Metastases from Radio-resistant and Radio-sensitive Primary Tumours

Hatef Mehrabian¹, Wilfred W Lam¹, Hany Soliman^1,2,3, Sten Myrehaug^2,3, Arjun Sahgal^1,2,3, and Greg J Stanisz^1,4

¹Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada, ²Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, ³Radiation Oncology, University of Toronto, Toronto, ON, Canada, ⁴Medical Biophysics, University of Toronto, Toronto, ON, Canada

Previous animal studies have shown differences in CEST properties of radio-resistant and radio-sensitive renal cell carcinoma xenografts. The current study probed the differences in CEST and MT properties of brain metastases from radio-resistant and radio-sensitive primary tumours. We observed significantly lower amount of magnetization transfer, RM_0B/R_A, and direct water saturation effect, 1/(R_AT_2A) in brain metastases from radio-resistant tumours compared to those from radio-sensitive tumours. However, the CEST effects of the two cohorts were not different. Such information should be considered when investigating brain metastases and their response to treatment.

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