The spin echo, full Intensity acquired localized (SPECIAL) sequence consists of a localized spin-echo, preceded by an alternating ISIS pre-inversion for voxel localization. In this study we modified the SPECIAL sequence to simultaneously localize the signal at two different positions. The technique relies on a four-step inversion scheme involving two different inversion positions, followed by a Hadamard encoding reconstruction. Comparing the in vivo performance of dual-SPECIAL sequence to the conventional SPECIAL sequence demonstrated that the dual-Special sequence provides simultaneous metabolite profile from two different regions, reducing the acquisition time by a factor of two, and without any penalty in SNR.
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