Abstract #0477

Detection of Multiple Nucleotide Sugars Including Uridine Diphosphate Hexoses and N-Acetyl Hexosamines in Human Brain by 31P MRS at 7T

Jimin Ren^1,2, Craig R Malloy^1,2,3, and A Dean Sherry^1,2,4

¹Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States, ²Department of Radiology, UT Southwestern Medical Center, Dallas, TX, United States, ³VA North Texas Health Care System, Dallas, TX, United States, ⁴Department of Chemistry, University of Texas at Dallas, Richardson, TX, United States

A variety of nucleotide sugars (NS) are required for glycosylation of proteins and lipids to enhance and diversify cellular functions. The current 7T ³¹P MRS study, for the first time, reports the detection of four different NS species in human brain in vivo. They are tentatively assigned to UDP-glucose, UDP-galactose, UDP-N-acetylglucosamine, and UDP-N-acetylgalactosamine, collectively denoted as UDP(G). These UDP(G) species are responsible for the observation of a “quartet-like” signal at -9.8 ppm, which cannot be explained by the presence of only a single UDP(G) species such as UDP-glucose (as expected to be a simple doublet).

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