As our understanding of cancer metabolism advances, novel methods are needed to dynamically assess its heterogeneity in preclinical models, with high temporal resolution. Here we show the feasibility of dynamic 2H-MRS in glioma-bearing mice to monitor glucose metabolism with <3s resolution. This was achieved with a new 2H/1H RF coil design for the mouse brain and a novel application of Marchenko–Pastur denoising. We are now adapting this methodology to 2H-MRSI, with high spatial resolution.
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