Abstract #0446

Voxel-wise comparison of co-registered quantitative CT and hyperpolarized gas diffusion-weighted MRI measurements in IPF

Ho-Fung Chan¹, Alberto Biancardi¹, Bilal A Tahir¹, Nicholas D Weatherley¹, Ronald A Karwoski², Brian J Bartholmai², Stephen M Bianchi³, and Jim M Wild¹

¹Academic Radiology, University of Sheffield, Sheffield, United Kingdom, ²Biomedical Imaging Resource, Mayo Clinic, Rochester, MN, United States, ³Academic Directorate of Respiratory Medicine, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom

A framework for spatial co-registration of ³He diffusion-weighted (DW)-MRI and high resolution CT (HRCT) images was developed and implemented in a cohort of fifteen idiopathic pulmonary fibrosis participants. Voxel-wise comparison of ³He DW-MRI derived apparent diffusion coefficient (ADC) and mean alveolar dimension (Lm_D) with CALIPER image analysis software classifications revealed that the largest DW-MRI metrics are in voxels classified as honeycombing. Furthermore, Lm_D values in voxels classified as normal by CALIPER were larger than those from age-matched healthy volunteers, suggesting DW-MRI may detect microstructural changes even in areas of the lung determined as macroscopically normal by HRCT.

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