Abstract #0444

Longitudinal lobar analysis to access variable dynamic airflow changes in asthma with hyperpolarized helium-3 MRI

Mu He¹, Lindsay A. L. Somerville¹, Nicolas J. Tustison², Jaime F. Mata², Joanne M. Cassani³, Roselove Nunoo-Asare², Alan M. Ropp², Wilson G. Miller², Yun M. Shim¹, Talissa A. Altes³, John P. Mugler², and Eduard E. de Lange²

¹Department of Pulmonary and Critical Care, University of Virginia, Charlottesville, VA, United States, ²Department of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA, United States, ³Department of Radiology, University of Missouri, Columbia, MO, United States

With hyperpolarized ³He MRI regional differences in airflow can be assessed. We sought to evaluate the changes in regional ventilation following bronchodilator therapy in patients with asthma. Baseline and post-treatment ³He/¹H scans were co-registered, and normalized to enable serial comparison. Linear binning quantification was applied to the ventilation scan data to obtain quantitative metrics. Baseline and post-treatment scans were compared for regions of ventilation improvement or worsening. Lobar analysis was performed to identify ventilation abnormalities in each lobe. It was found that in asthmatics with bronchodilator response, ventilation improved globally, with most significant improvement in the upper and middle lobes.

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