Abstract #0412

Pharmacokinetic analysis of DCE-MRI in pituitary adenoma: evaluation of tumor consistency and comparison with histological collagen content

Kiyohisa Kamimura¹, Masanori Nakajo¹, Tomohide Yoneyama¹, Manisha Bohara¹, Yoshihiko Fukukura¹, Shingo Fujio², Takashi Iwanaga³, Hiroshi Imai⁴, Marcel Dominik Nickel⁵, and Takashi Yoshiura¹

¹Radiology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan, ²Neurosurgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan, ³Clinical Engineering Department Radiation Sectio, Kagoshima University Hospital, Kagoshima, Japan, ⁴Siemens Healthcare K.K., Tokyo, Japan, ⁵Siemens Healthcare, Erlangen, Germany

Preoperative information of tumor consistency is important in patients with pituitary adenoma. Our aim was to evaluate the possible role of high-temporal and spatial resolution dynamic contrast enhanced MR imaging (DCE-MRI) and quantitative pharmacokinetic analysis in differentiation of a hard adenoma from soft adenoma. The hard adenoma showed significantly higher extravascular extracellular space per unit volume of tissue (v_e) than soft adenoma and the v_e was significantly correlated to collagen IV content of pituitary adenomas. This quantitative pharmacokinetic parameter v_e may be useful for differentiation of the hard adenoma from soft adenoma.

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