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Abstract #0398

Metabolic characterization of human glioma subtypes using simultaneous pH- and oxygen-sensitive amine CEST-SAGE-EPI

Jingwen Yao1,2,3, Talia Oughourlian1,2,4, Timothy Cloughesy5,6, Phioanh L. Nghiemphu5,6, Albert Lai5,6, Linda M. Liau7, Richard G. Everson7, Whitney B. Pope2, Noriko Salamon2, David A. Nathanson8, and Benjamin M. Ellingson1,2,3,4,5
1Brain Tumor Imaging Laboratory (BTIL), Center of Computer Vision and Imaging Biomarker, David Geffen School of Medicine, UCLA, Los Angeles, CA, United States, 2Department of Radiological Sciences, David Geffen School of Medicine, UCLA, Los Angeles, CA, United States, 3Department of Bioengineering, Henry Samueli School of Engineering and Applied Science, UCLA, Los Angeles, CA, United States, 4Neuroscience Interdepartmental Program, David Geffen School of Medicine, UCLA, Los Angeles, CA, United States, 5UCLA Neuro-Oncology Program, David Geffen School of Medicine, UCLA, Los Angeles, CA, United States, 6Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA, United States, 7Department of Neurosurgery, David Geffen School of Medicine, UCLA, Los Angeles, CA, United States, 8Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, CA, United States

We simultaneously quantified acidity and hypoxia of human gliomas with IDH, 1p/19q, and EGFR genotypes using CEST-SAGE-EPI. Results suggest IDH mutant gliomas are significantly less acidic and hypoxic than IDH wild-type tumors. Within IDH mutants, 1p/19q codeletion is associated with lower tumor acidity, while IDH wild-type, EGFR amplified tumors were more hypoxic. Both MRI-derived acidity and hypoxia were correlated with patient survival, suggesting metabolic characteristics may be prognostic. CEST-SAGE-EPI may be useful for exploring metabolic changes that result from particular genetic alterations or useful as a biomarker for accelerating drug development in human brain tumors.

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