Abstract #0383

Penumbra Identification in Acute Stroke Using Fast 3D 1H-MRSI

Yao Li¹, Zengping Lin¹, Tianyao Wang², Tianxiao Zhang¹, Rong Guo^3,4, Yudu Li^3,4, Yibo Zhao^3,4, Ziyu Meng^1,3, Jun Liu², Xin Yu⁵, and Zhi-Pei Liang^3,4

¹Institute for Medical Imaging Technology, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China, ²Radiology Department, The Fifth People's Hospital of Shanghai, Fudan University, Shanghai, China, ³Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ⁴Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ⁵Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States

Impaired metabolism was a key factor in the definition of ischemic penumbra. ¹H-MRSI has been recognized as a potentially powerful tool for metabolic imaging of stroke. In this proof of concept clinical study, we explored the potential of fast 3D high-resolution ¹H-MRSI to investigate brain neurometabolic changes at tissue-level in acute stroke. In a 6-min scan, we obtained N-acetylaspartate (NAA) and lactate (Lac) maps simultaneously. Our experimental results showed different NAA and Lac concentrations between hypoperfused tissue recruited to final infarct and that survived, indicating an improved delineation of penumbra by incorporating the tissue neuronal damage and acidosis information.

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