Abstract #0374

Quantification of phenylalanine with 1H MRS using optimized acquisition conditions and downfield background modeling

Maike Hoefemann¹, Raphaela Muri², Stephanie Abgottspon², Johannes Slotboom³, Regula Everts^2,4, Roman Trepp², and Roland Kreis¹

¹Departments of Radiology and Biomedical Research, University of Bern, Bern, Switzerland, ²Department of Diabetes, Endocrinology, Clinical Nutrition and Metabolism, Bern University Hospital, University of Bern, Bern, Switzerland, ³Support Center for Advanced Neuroimaging, University Institute of Diagnostic and Interventional Neuroradiology Inselspital, Bern, Switzerland, ⁴Division of Neuropediatrics, Development & Rehabilitation, Pediatric University Hospital, University of Bern, Bern, Switzerland

For the quantification of the low-concentration metabolite phenylalanine (Phe) in patients with phenylketonuria using ¹H magnetic resonance spectroscopy, optimal acquisition parameters and fitting procedures are crucial. Using a large voxel size and short TE helps to increase the signal-to-noise-ratio and allows restriction to a measurement time of 12min. Using the comparison of healthy controls vs. patients affords modeling of the unknown downfield region to develop a robust fitting model. Low CRLB of around 0.004mM proved the good precision of the quantification results, yielding cohort values of 0.019±0.01mM in controls and 0.142±0.02mM in patients.

This abstract and the presentation materials are available to members only; a login is required.

Join Here